Modulation of osteoclastogenesis by antihypertensive drugs

Negative modulation of human osteoclastogenesis by antiepileptic drugs

1 Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, Portugal. 2 CISA/CQB Escola Superior de Tecnologia da Saúde do Porto Instituto Politécnico do Porto, Portugal. 3 REQUIMTE-CQFB, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Portugal. 4 Centro de Farmacologia e Biopatologia Química (U38-FCT), Faculty of Medicine, University o...

Modulation of potassium channels by antiarrhythmic and antihypertensive drugs.

Agents that modulate cardiac and smooth muscle K+ channels have stimulated considerable interest in recent years because of their therapeutic potential in a number of cardiovascular diseases. Foremost among these drugs are the so-called Class III antiarrhythmic agents, which act by prolonging cardiac action potentials, and K+ channel openers, which hyperpolarize and thereby relax smooth muscle ...

THE EFFECT OF ANTIHYPERTENSIVE DRUGS IN THE SUPPRESSION OF ATHEROSCLEROSIS

The present investigation was undertaken to evaluate the effect of antihypertensive drugs on aortic atherogenesis in hypercholesterolemic rabbits. In enalapril and nifedipine treated rabbits aortic atherosclerotic plaque involvement was significantly decreased (p<0. Oland p<O. 05, respectively) as compared to the control group. However, in hydrochlorothiazide treated rabbits aortic atheroge...

Antihypertensive Drugs

Hypertension is one of the most serious concerns of modern medical practice. It is estimated that in the United States, as many as 60 million people are hypertensive or are being treated with antihypertensive drugs. Among the growing population of elderly Americans, some 15 million have high blood pressure. The level of blood pressure in itself is not a chief concern, since individuals with hig...

Antihypertensive drugs in pregnancy.